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Louisville is a slight road favorite against Clemson on Saturday.

Louisville vs. Clemson Prediction, Odds for College Basketball on Saturday, Feb. 28

Iain MacMillan

|

Feb 28, 2026

Mar 14, 2025; Charlotte, NC, USA; Louisville Cardinals guard J'Vonne Hadley (1) drives to the basket against Clemson Tigers forward Ian Schieffelin (4) during the second half at Spectrum Center. Mandatory Credit: Jim Dedmon-Imagn Images

Preview: Louisville Hopes to Bounce Back in Road Trip to Clemson

Matthew McGavic

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Feb 28, 2026

Louisville Cardinals guard Mikel Brown Jr. (0) drives the basket as the Louisville Cardinals host the Georgia Tech Yellow Jackets in an NCAA basketball game at the KFC Yum! Center, Saturday, Feb. 21, 2026, in Louisville.

ACC Releases Preliminary Injury Report for Louisville vs. Clemson

Matthew McGavic

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Feb 27, 2026

Clemson guard Jake Wahlin (10) reacts after defending Florida State University forward Chauncey Wiggins (7) during the first half at Littlejohn Coliseum in Clemson, S.C Saturday, February 21, 2026.

How to Watch Clemson Tigers Basketball vs. No. 24 Louisville

Griffin Barfield

|

Mar 20, 2026

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Louisville Cardinals head coach Pat Kelsey looks up at the scoreboard as the Louisville Cardinals host the Georgia Tech Yellow Jackets in an NCAA basketball game at the KFC Yum! Center, Saturday, Feb. 21, 2026, in Louisville.

Watch: Pat Kelsey, Louisville Players Preview Matchup vs. 'Extremely Well Coached' Clemson Squad

Matthew McGavic

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Feb 27, 2026

Mar 14, 2025; Charlotte, NC, USA; Louisville Cardinals guard J'Vonne Hadley (1) goes to the basket against Clemson Tigers center Viktor Lakhin (0) during the second half at Spectrum Center. Mandatory Credit: Jim Dedmon-Imagn Images

Tale of The Tape, Predictions: Louisville vs. Clemson

Matthew McGavic

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Feb 26, 2026

Mar 14, 2025; Charlotte, NC, USA; Louisville Cardinals guard J'Vonne Hadley (1) makes contact with Clemson Tigers guard Jaeden Zackery (11) during the second half at Spectrum Center. Mandatory Credit: Jim Dedmon-Imagn Images

How to Watch Louisville's Showdown at Clemson

Matthew McGavic

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Feb 26, 2026

Clemson is hoping to snap a four-game losing streak on Saturday against Louisville.

Clemson’s Next Opponent, Louisville, Has One Glaring Problem

Drew Cagle

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Feb 25, 2026

Kymora Johnson (right) and Virginia took down No. 8 Louisville on Sunday.

Women’s Basketball Bubble Watch: Virginia and Clemson Make a Statement

Blake Silverman

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Feb 25, 2026

Clemson Tigers guard Zac Foster tore his ACL back in December, being more than two months into his recovery.

Clemson Guard Zac Foster Reveals Recovery Process After Season-Ending Injury

Griffin Barfield

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Feb 24, 2026

Florida State University forward Chauncey Wiggins (7) takes a shot near Clemson forward Chase Thompson (3) during the first half at Littlejohn Coliseum in Clemson, S.C Saturday, February 21, 2026.

Clemson Head Coach Brad Brownell Reveals Biggest Issue From Four-Game Skid

Griffin Barfield

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Feb 23, 2026

Clemson guard Ace Buckner was a clear bright spot in the Tigers' loss to Florida State.

What Ace Buckner’s Emergence Means for Clemson Basketball

Drew Cagle

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Feb 23, 2026

Clemson freshman Zac Foster (5) tore his ACL in December, not playing in conference play this season.

The One Player Clemson Basketball Could Really Use Right Now

Ethan Silipo

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Feb 23, 2026

Clemson head coach Shawn Poppie has the Tigers on the brink of reaching their first NCAA Tournament since 2018-19.

Shawn Poppie, Clemson Women’s Basketball Nears NCAA Lock With Electrifying Ranked Win

Griffin Barfield

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Feb 22, 2026

Clemson guard Butta Johnson (4) brings the ball upcourt against Florida State University during the second half at Littlejohn Coliseum in Clemson, S.C Saturday, February 21, 2026.

Clemson Slips From March Madness Lock: What Needs to Happen

Ethan Silipo

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Feb 22, 2026

Clemson guard Ace Buckner(21) rebounds against Florida State University during the first half at Littlejohn Coliseum in Clemson, S.C Saturday, February 21, 2026.

Why Clemson Basketball's Lack of Elite Scoring Could Define Its Postseason

Griffin Barfield

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Feb 22, 2026

Clemson basketball suffered its fourth-straight loss of the season to Florida State on Saturday.

What Went Wrong: Clemson Loses Fourth Straight to Florida State at Home

Griffin Barfield

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Feb 21, 2026

Florida State Seminoles guard Robert McCray V shoots against Clemson Tigers guard Dillon Hunter | February, 21, 2026

3 Takeaways as FSU Basketball Continues Hot Streak, Upsets Clemson on the Road

Austin Veazey

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Feb 21, 2026

Clemson’s deputy athletic director is expected to leave for a Group of Five athletic director position.

Clemson Deputy AD Set to Take Athletic Director Role at Group of Five Program, per Reports

Angelo Feliberty

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Feb 21, 2026

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